Home Forums Checkpoint Pathway PD-L1 What is PD-L1

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  • Steve Hoimes
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    What
    Pd-l1 is a ligand protein that is expressed on the surface of a healthy cell.

    Function
    Pd-l1 binds with Pd-1 checkpoint ligand on the surface of T-CellS.

    Binding
    The binding of these ligands is called the checkpoint pathway.

    Checkpoint pathway purpose
    When a Healthy cell is approached by a T Cell that is primed to attack, the T Cell has a checkpoint switch called Pd-1 (ligand) which can down regulate (stop) an accidental attack on healthy cells.

    A healthy cell will express the Pd-l1 ligand on its surface when confronted by a T Cell and bind with the T Cells Pd-1 – a handshake between friends.

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